Akromegalie
Originalarbeit – Impact of Disease Duration on Coronary Calcification in Patients with Acromegaly
Impact of Disease Duration on Coronary Calcifi cation
in Patients with Acromegaly
It has been shown, that the prevalence of myocardial
infarction is similar to that observed in
the general population, whereas arrhythmias are
frequent in patients with acromegaly and may be
due to cardiomegaly [4, 5] . Autoptic studies demonstrated
that severe coronary atherosclerosis
are detectable only in patients with long-term
acromegaly [6] . Disease control seems to infl uence
alterations of arteries, regarding the observations
that intima-media thickness of the
carotid arteries were increased in about 50 % of
patients and normalized after cure or disease
control [7] .
Wirksame Medikation gegen Akromegalie
Wirksame Medikation gegen Akromegalie
und Cholesterinspiegel wieder normalisieren.
Mittel der Wahl sind die operative Entfernung des Hypophysentumors,gefolgt zum Teil von Strahlentherapie und medikamentöser Behandlung.
Mit Pregvisomant (Somavert®), einemAntagonisten des Wachstumshormonrezeptors,steht ein Medikament zur Verfügung, das gute Heilungsraten verspricht.
Originalarbeit Akromegalie – evidence for a direct relation between disease activity and cardiac dysfunction in patients without ventricular hypertrophy
Clinical Endocrinology (2002) 56, 595–602
© 2002 Blackwell Science Ltd 595
Blackwell Science, Ltd Acromegaly: evidence for a direct relation between
disease activity and cardiac dysfunction in patients
without ventricular hypertrophy
B. L. Herrmann*, C. Bruch†, B. Saller*, T. Bartel†,
S. Ferdin*, R. Erbel† and K. Mann*
Divisions of *Endocrinology and †Cardiology, University of
Essen, Essen, Germany
(Received 4 July 2001; returned for revision 10 October 2001;
finally revised 7 November 2001; accepted 29 January 2002)
Summary
BACKGROUND AND AIMS Cardiac abnormalities, such
as cardiomegaly and congestive heart failure, occur
frequently in advanced acromegaly. Abnormalities of
systolic and diastolic function, mostly associated with
left ventricular (LV) hypertrophy, have been reported.
The impact of disease activity on LV performance in
patients with normal or slightly elevated LV muscle
mass has not been demonstrated.
